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MiraXion® is
a new medicinal product for the treatment of Huntington's
disease. The product is designated as an Orphan Medicinal Product
by both the FDA and the EMEA. MiraXion is currently in Phase
III clinical trials conducted by Amarin Neuroscience Ltd.. Scil
Technology retains the marketing rights to MiraXion in certain
European countries such as Germany, France, BeNeLux, Austria, Switzerland,
Poland, Czech Republic, Slovakia and Turkey.
MiraXion® is a semi-synthetic, highly purified
derivative of the n-3 fatty acid eicosapentaenoate (EPA). The mechanism
of action is believed to involve the stabilisation of mitochondrial
integrity in compromised neurons, thereby preventing or slowing
progression from neuronal dysfunction to cell death.
Huntington´s disease,
previously known as Huntington's chorea, is a rare, hereditary
neurodegenerative brain disease. It is characterised by
a combination of movement abnormalities and personality changes progressing
to mental dementia. Onset of the disease is usually in the fourth
decade of life but may also occasionally occur in early childhood
or late life. The symptoms consist of choreatic movement disorders
in addition to a progressive loss of control of the fine motor movements.
In the early stages of the disease, activities such as tying shoe
laces or holding a glass without spilling the contents become difficult.
As the disease progress, there are organic personality
changes and, in the final stage of the disease, there is a profound
dementia.
Further information on MiraXion® can be found here: http://www.amarincorp.com/news.cfm
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